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Lollipop Chainsaw comes in different single-player and multiplayer versions, based on an advance level system, and two different controllers, one for each version. Content on this page comes directly from press releases and fact sheets provided by publishers and developers and was not written by the Game Revolution staff. the protocol is routinely used in clinical practice for all hospitalized patients. The analysis of the data revealed that prescription of combination therapy is not in accordance with the current guidelines for secondary preventive therapy. Patients with no hypoglycemic drugs were more likely to be prescribed combined therapy. Regarding the prescription of statins, we found that 75% of the patients received a single statin, and 25% were given combination therapy. Analysis of individual classes of hypoglycemic drugs revealed that only metformin was frequently prescribed. The combination therapy of sulfonylurea and metformin was the most common drug combination, as prescribed for 39% of the patients. Furthermore, combination therapy of DPP-4 inhibitors and metformin, and that of GLP-1 receptor agonists with metformin, were prescribed to 21% and 11% of the patients, respectively. The guidelines of the European Association for the Study of Diabetes recommend against combined therapy with a sulfonylurea and metformin ([@B5]), although they note that "it may be considered in patients with cardiovascular risk factors, in patients with a history of cardiovascular disease and/or heart failure" ([@B5]). The guidelines of the American Diabetes Association recommend sulfonylureas with metformin in patients with cardiovascular disease or heart failure ([@B4]), but they acknowledge that evidence is insufficient for other patients ([@B4]). The analysis of the data revealed several observations. First, the rate of combination therapy was highest for patients with no hypoglycemic drugs. A possible explanation for this finding may be that physicians are well aware of the side effects of single-agent hypoglycemic treatment and are more prone to prescribe combination therapy. Second, the prevalence of combination therapy was highest for patients with pre-existing cardiovascular disease and the presence of any cardiovascular risk factors. This may be explained by a perceived need for additional antihypertensive therapy in patients with such diseases, which may in turn raise the threshold for the prescription of hypoglycemic drugs. The analysis of individual classes of hypoglycemic drugs revealed that metformin was the most frequent drug of choice. The current guidelines ([@B5],[@B

 

 

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